These are the main thermal sites of the Region with the characteristic of their waters:
- Acquasanta (TR): bicarbonate-alcaline cold waters (14°C);
- Assisi (PG): bicarbonate-calcic cold waters (15,2°C);
- Città di Castello (PG): bicarbonate-alcaline-suphureous cold waters (16°C);
- Massa Martana (PG): carbonate-bicarbonate-calcic-alcaline cold waters;
- San Gemini (TR): bicarbonate-calcic cold waters (113-15°C);
- Spello (PG): mineral-sulphureous-bicarbonate-alcaline waters.